Langerhans Cells Orchestrate TFH-Dependent Humoral Immunity

B cells and humoral immunity in atherosclerosis.

Insights into the important contribution of inflammation and immune functions in the development and progression of atherosclerosis have greatly improved our understanding of this disease. Although the role of T cells has been extensively studied for decades, only recently has the role of B cells gained more attention. Recent studies have identified differential effects of different B-cell subs...

Reduced T-dependent humoral immunity in CD20-deficient mice.

CD20 is a tetraspanning membrane protein expressed on B lymphocytes. CD20 deficiency in both mice and humans has recently been shown to have deleterious effects on Ab responses to T-independent Ags; however, no effect on T-dependent immunity has been reported. In this study, we used a Cd20⁻/⁻ mouse line to evaluate Ab responses to adeno-associated virus and SRBCs. The neutralizing Ab response t...

Humoral immunity in cardiomyopathy.

Sera from patients with heart disease were examined by single sandwich indirect immunofluorescence for the presence of antibodies to human heart muscle. Endocardial biopsy specimens were also examined by direct immunofluorescence for deposition of antibodies in vivo. No consistent or specific abnormality was found in the biopsy specimens or sera of patients with congestive cardiomyopathy. The p...

Cellular and Humoral Immunity

The Abstract was presented at the Fourth Herpes Virus Meeting, Cold Spring Harbor, N. Y. Dr. Pollard's present address is Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas. Received for publicatiotn 2 October 1979 anid inl revised forimi 14 December 1979. recovery of phytohemagglutinin transformation often preceded recovery of the responses to viral antigens....

Persisting Humoral Antiviral Immunity